| ncRNA name | rno-miR-29c |
| ncRNA Category | miRNA |
| Disease name | age-related cataract |
| Species | Rattus norvegicus |
| Tissues/Cell_line | lens; lens epithelial cells (LECs) |
| Methods | microarray, qRT-PCR, transfection, protein blot, luciferase reporter assay |
| Expression pattern | up-regulated |
| Functional description | The cytoskeleton remodelling genes tropomyosin (Tm) 1α and 2β, which have been implicated in the initiation of pathophysiology, were targets of miR29c and were over-stimulated as demonstrated by inhibitor experiments. In transfection experiments, increasing the level of miR29c caused a corresponding decrease in the expression of Tm1α and 2β, suggesting that miR29c may regulate the translation of Tm1α and 2β. |
| PubMed ID | 23844765 |
| Year | 2013 |
| Title | Dynamic and differential regulation in the microRNA expression in the developing and mature cataractous rat lens. |
| Drug-related ncRNA | NO |
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